Journal Club: Tracking a complete voltage-sensor cycle with metal-ion bridges

Posted by lettsscience on August 26, 2012 · 7 Comments 

In this post I would like to start an online discussion about a very interesting recent PNAS paper: Tracking a complete voltage-sensor cycle with metal-ion bridges by Henrion et al. I know that other people in the voltage-gated cation channel field are very interested in this paper and it also relates to many of the … Continue reading →

Filed under Biochemistry, Biophysics, Ion channels, Journal Club, Science, Voltage gating

Omega Current Channelopathies

Posted by lettsscience on August 20, 2012 · 4 Comments 

In this post I will be continuing my series on the omega current. The omega current is a leak current that passes through the voltage-sensor domain (VSD) of mutated voltage-gated cation channels. Mutation of the VSD S4 helix can reveal a cryptic pore that allows ions (H+, Li+, K+, Rb+ and even guanidinium) to cross … Continue reading →

Filed under Biochemistry, Biophysics, Ion channels, Opinion, Physiology, Review, Science, Voltage gating · Tagged with , , , , , , , , , , , , , , , ,