Posted by lettsscience on August 20, 2012 · 4 Comments
In this post I will be continuing my series on the omega current. The omega current is a leak current that passes through the voltage-sensor domain (VSD) of mutated voltage-gated cation channels. Mutation of the VSD S4 helix can reveal a cryptic pore that allows ions (H+, Li+, K+, Rb+ and even guanidinium) to cross … Continue reading →
Filed under Biochemistry, Biophysics, Ion channels, Opinion, Physiology, Review, Science, Voltage gating · Tagged with 6TM channels, Benign familial neonatal epilepsy, channelopathy, hypkalemic periodic paralysis, ion channels, omega current, omega pore, Opinion, Peripheral nerve hyperexcitability, protein architechture, protein structure function, Review, S4 helix, science, voltage gating, voltage sensor domain, voltage-gated cation channels
LettsScience 