Hv Physiology: Brain Damage

Thanks to the groundbreaking work of Hodgking and Huxley, the most well known physiological role of voltage-gated ion channels is the propagation of the action potential in neurons (Hodgkin & Huxley, 1952). What Hodgkin and Huxley demonstrated was that the action potential is generated by the sequential opening and closing of voltage-gated Na+ and K+ … Continue reading

Hv Physiology: Human Male Fertility

The human voltage-gated proton channel Hv1 plays an important physiological role in male fertility in humans. Specifically it is integral for regulation of the internal pH of the sperm cell. The pH of the sperm cytoplasm is a major regulator of sperm cell motility, capacitation, hyperctivation and the acrosome reaction. Each of these processes are … Continue reading

I work on Hv

I am currently working on the human voltage-gated proton channel Hv1. My main goal is to solve the structure of this protein by any means necessary. The first approach has been to try and get crystals of the protein to use in diffraction experiments. This has proven to be extremely difficult! Let me just say … Continue reading