I work on Hv
I am currently working on the human voltage-gated proton channel Hv1. My main goal is to solve the structure of this protein by any means necessary.
The first approach has been to try and get crystals of the protein to use in diffraction experiments. This has proven to be extremely difficult! Let me just say that after working on this problem for two years I managed to get crystals that diffracted to moderate resolution and was able to solve a structure! However, it turned out that the protein was is a non-native partially unfolded state and therefore we were not able to learn anything about its proper structure or how the protein works. Science is hard! But I haven’t given up.
The structure of Hv would be a major break through. I will certainly be elaborating more in this blog about why Hv is important and why I feel proud to be dedicating my time and effort into advancing our understanding of this molecule.